Mechanistic modelling of human disease

We develop mechanistic models to understand pathophysiological mechanisms, focusing on dynamic immune responses to external stimuli (pathogens, environmental factors, treatments). Understanding of disease mechanisms will help design effective treatment strategies.

Model-based meta-analysis to optimise $\mathit{S.}$ $\mathit{aureus}$-targeted therapies for atopic dermatitis
Takuya Miyano, Alan D. Irvine, Reiko Tanaka
Cite Code DOI MedRxiv
A mathematical model to identify optimal combinations of drug targets for dupilumab poor responders in atopic dermatitis
Takuya Miyano, Alan D. Irvine, Reiko Tanaka
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Model Predictive Control for Designing Proactive Therapy of Atopic Dermatitis
Atopic dermatitis (AD) is a chronic inflammatory skin disease, affecting up to 25% of children worldwide. While the current mainstay of …
Anastasia G. Giannari, Mark D.A. Van Logtestijn, Panayiotis Christodoulides, Katsumi Konishi, Reiko Tanaka
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Bifurcation analysis of a mathematical model of atopic dermatitis to determine patient-specific effects of treatments on dynamic phenotypes
Atopic dermatitis (AD) is a common inflammatory skin disease, whose incidence is currently increasing worldwide. AD has a complex …
Gouhei Tanaka, Elisa Domínguez-Hüttinger, Panayiotis Christodoulides, Kazuyuki Aihara, Reiko Tanaka
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Mathematical modeling of atopic dermatitis reveals “double-switch” mechanisms underlying 4 common disease phenotypes
Background The skin barrier acts as the first line of defense against constant exposure to biological, microbial, physical, and …
Elisa Domínguez-Hüttinger, Panayiotis Christodoulides, Kosuke Miyauchi, Alan D. Irvine, Mariko Okada-Hatakeyama, Masato Kubo, Reiko Tanaka
Cite DOI Media coverage: article in Imperial News Media coverage: Latest Research Summaries for American Academy of Allergy Asthma and Immunology
Mathematical modeling of $\mathit{Streptococcus}$ $\mathit{pneumoniae}$ colonization, invasive infection and treatment
Streptococcus pneumoniae (Sp) is a commensal bacterium that normally resides on the upper airway epithelium without causing infection. …
Elisa Domínguez-Hüttinger, Neville J. Boon, Thomas B. Clarke, Reiko Tanaka
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Computational design of treatment strategies for proactive therapy on atopic dermatitis using optimal control theory
Panayiotis Christodoulides, Yoshito Hirata, Elisa Domínguez-Hüttinger, Simon G. Danby, Michael J. Cork, Hywel C. Williams, Kazuyuki Aihara, Reiko Tanaka
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In silico modeling of spore inhalation reveals fungal persistence following low dose exposure
The human lung is constantly exposed to spores of the environmental mould Aspergillus fumigatus, a major opportunistic pathogen. The …
Reiko Tanaka, Neville J. Boon, Katarina Vrcelj, Anita Nguyen, Carmelina Vinci, Darius Armstrong-James, Elaine Bignell
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