Modelling the influence of foot-and-mouth disease vaccine antigen stability and dose on the bovine immune response


Foot and mouth disease virus causes a livestock disease of significant global socio-economic importance. Advances in its control and eradication depend critically on improvements in vaccine efficacy, which can be best achieved by better understanding the complex within-host immunodynamic response to inoculation. We present a detailed and empirically parametrised dynamical mathematical model of the hypothesised immune response in cattle, and explore its behaviour with reference to a variety of experimental observations relating to foot and mouth immunology. The model system is able to qualitatively account for the observed responses during in-vivo experiments, and we use it to gain insight into the incompletely understood effect of single and repeat inoculations of differing dosage using vaccine formulations of different structural stability.

PLoS ONE, vol. 7, no. 2, p. e30435, Feb. 2012
Reiko Tanaka
Reiko Tanaka
Reader in Computational Systems Biology & Medicine